The connectome of the adult Drosophila mushroom body provides insights into function

Feng Li et al.
eLife. December 2020

CLIENT

Rubin Lab, HHMI Janelia

TOOLS

Adobe Illustrator, Adobe Premiere Pro, neuPrint, neuTu, neuVid, Blender, Cytoscape

DATA

Hemibrain connectome (Scheffer et al. 2020)

Contributions

Paper Summary

The Mushroom Body (MB) is an extensively studied area in the brain of Drosophila Melanogaster involved in learning, memory, and activity regulation. This paper describes  new insights revealed by the hemibrain dataset about the MB circuit. It details atypical MB output neurons (MBONs), which output directly to ventral brain regions and descending neurons as well as direct visual input into the MB. It provides insights about the circuity used to integrate MB outputs including connections to the Central Complex (CX).

Figure 20-figure supplement 1
Figure 24
Figure 23
Figure 40

Video 2 | MB Compartments

Video 2 | Kenyon Cell (KC) Lineage

Figure 41

Atypical Mushroom Body Output Neurons (MBONs)

Video 7 | Atypical MBON10

Figure 8-figure supplement 1

Video 12 | Atypical MBON27

Figure 8-figure supplement 6

Video 20 | Atypical MBON35

Figure 8-figure supplement 14

Video 27 | MBON to CX

Video 24 | MBON06

Figure 26
Figure 19

Video  32 | PAM11

Video 33| PAM12